ARID1A mutations in cancer: another epigenetic tumor suppressor?

ABSTRACT:

Unlabelled

Although disordered chromatin organization has long been recognized as a feature of cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their relationships to transcription are only beginning to be understood. Cancer genome sequencing studies have revealed a novel theme: frequent mutation of epigenetic regulators. Among these, the ARID1A/BAF250A subunit of the SWI/SNF (BRG1-associated factors) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types. We review the genomic and functional data supporting classification of ARID1A as a tumor suppressor.

Significance

Mutations in chromatin remodeling complex genes are increasingly recognized in many cancer types. However, the mechanisms by which

SUBMITTER: Wu JN 

PROVIDER: S-EPMC3546152 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature