Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials.

ABSTRACT:

Background

Cognitive impairment is common in patients with end-stage renal disease receiving hemodialysis 3 times per week.

Study design

Randomized clinical trial.

Setting & participants

218 individuals participating in the Frequent Hemodialysis Network (FHN) Daily Trial and 81 participating in the FHN Nocturnal Trial.

Intervention

The Daily Trial tested in-center hemodialysis 6 times per week versus 3 times per week. The Nocturnal Trial tested home nocturnal hemodialysis 6 times per week versus home or in-center hemodialysis 3 times per week.

Outcomes

Cognitive function was measured at baseline, month 4, and month 12. The primary outcome was performance on the Trail-Making Test, Form B, a measure of executive function, and a secondary outcome was perfor

SUBMITTER: Kurella Tamura M 

PROVIDER: S-EPMC3546160 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature