Impact of reproductive status and age on response of depressed women to cognitive therapy.

ABSTRACT:

Objective

Previous research suggests that reproductive hormones are potential affective modulators in mood disorders and may influence response to antidepressant medications. To our knowledge, there are no data on relationships between hormonal status and response to psychotherapy for recurrent major depressive disorder (MDD).

Methods

At two sites, female outpatients (n=353), aged 18-70, with recurrent MDD received 12-14 weeks of cognitive therapy (CT). Menopausal status and age were based on self-report. In the parent study, nonresponse to therapy was defined as persistence of a major depressive episode (MDE) as defined by the DSM-IV or a final Hamilton Rating Scale for Depression-17-Item (HRSD(17)) score of ≥ 12 or both. More traditional definitions of response (at least a

SUBMITTER: Brandon AR 

PROVIDER: S-EPMC3546363 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature