Molecular characterisation of cell line models for triple-negative breast cancers.

ABSTRACT:

Background

Triple-negative breast cancers (BC) represent a heterogeneous subtype of BCs, generally associated with an aggressive clinical course and where targeted therapies are currently limited. Target validation studies for all BC subtypes have largely employed established BC cell lines, which have proven to be effective tools for drug discovery.

Results

Given the lines of evidence suggesting that BC cell lines are effective tools for drug discovery, we assessed the similarities between triple-negative BCs and cell lines, to identify in vitro representatives, modelling the diversity within this BC subtype. 25 BC cell lines, enriched for those lacking ER, PR and HER2 expression, were subjected to transcriptomic, genomic and epigenomic profiling analyses and comparisons wer

SUBMITTER: Grigoriadis A 

PROVIDER: S-EPMC3546428 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature