Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis.

ABSTRACT:

Objective

To clarify whether any particular β blocker is superior in patients with heart failure and reduced ejection fraction or whether the benefits of these agents are mainly due to a class effect.

Design

Systematic review and network meta-analysis of efficacy of different β blockers in heart failure.

Data sources

CINAHL(1982-2011), Cochrane Collaboration Central Register of Controlled Trials (-2011), Embase (1980-2011), Medline/PubMed (1966-2011), and Web of Science (1965-2011).

Study selection

Randomized trials comparing β blockers with other β blockers or other treatments.

Data extraction

The primary endpoint was all cause death at the longest available follow-up, assessed with odds ratios and Bayesian random effect 95% credible intervals, with ind

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC3546627 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature