A system for exact and approximate genetic linkage analysis of SNP data in large pedigrees.

ABSTRACT:

Motivation

The use of dense single nucleotide polymorphism (SNP) data in genetic linkage analysis of large pedigrees is impeded by significant technical, methodological and computational challenges. Here we describe Superlink-Online SNP, a new powerful online system that streamlines the linkage analysis of SNP data. It features a fully integrated flexible processing workflow comprising both well-known and novel data analysis tools, including SNP clustering, erroneous data filtering, exact and approximate LOD calculations and maximum-likelihood haplotyping. The system draws its power from thousands of CPUs, performing data analysis tasks orders of magnitude faster than a single computer. By providing an intuitive interface to sophisticated state-of-the-art analysis tools coupled wit

SUBMITTER: Silberstein M 

PROVIDER: S-EPMC3546794 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature