IBAG: integrative Bayesian analysis of high-dimensional multiplatform genomics data.

ABSTRACT:

Motivation

Analyzing data from multi-platform genomics experiments combined with patients' clinical outcomes helps us understand the complex biological processes that characterize a disease, as well as how these processes relate to the development of the disease. Current data integration approaches are limited in that they do not consider the fundamental biological relationships that exist among the data obtained from different platforms. Statistical Model: We propose an integrative Bayesian analysis of genomics data (iBAG) framework for identifying important genes/biomarkers that are associated with clinical outcome. This framework uses hierarchical modeling to combine the data obtained from multiple platforms into one model.

Results

We assess the performance of our methods

SUBMITTER: Wang W 

PROVIDER: S-EPMC3546799 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature