Cigarette experimentation and the population attributable fraction for associated genetic and non-genetic risk factors.

ABSTRACT:

Background

We, and others, have shown that experimenting with cigarettes is a function of both non-genetic and genetic factors. In this analysis we ask: how much of the total risk of experimenting with cigarettes, among those who had not experimented with cigarettes when they enrolled in a prospective cohort, is attributable to genetic factors and to non-genetic factors?

Methods

Participants (N = 1,118 Mexican origin youth), recruited from a large population-based cohort study in Houston, Texas, provided prospective data on cigarette experimentation over three years. Non-genetic data were elicited twice - baseline and follow-up. Participants were genotyped for 672 functional and tagging variants in the dopamine, serotonin and opioid pathways.

Results

In the overall mo

SUBMITTER: Wilkinson AV 

PROVIDER: S-EPMC3547034 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature