Pharmacogenetics of antipsychotics: recent progress and methodological issues.

ABSTRACT:

Introduction

Antipsychotic drug is the mainstay of treatment for schizophrenia, and there are large inter-individual differences in clinical response and side effects. Pharmacogenetics provides a valuable tool to fulfill the promise of personalized medicine by tailoring treatment based on one's genetic markers.

Areas covered

This article reviews the recent progress in pharmacogenetic research of antipsychotic drugs since 2010, focusing on two areas: antipsychotic-induced weight gain and clozapine-induced agranulocytosis. The article also provides discussion on the important methodological issues in this area of research. The specific aim of this article is to provide the reader with up-to-date evidence in pharmacogenetic research, and for them to gain familiarity to the issu

SUBMITTER: Zhang JP 

PROVIDER: S-EPMC3547146 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature