Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children.

ABSTRACT:

Objective

To determine the effect of bovine lactoferrin (bLF) on prevention of diarrhea in children.

Study design

We conducted a community-based randomized double-blind placebo controlled trial comparing supplementation with bLF vs placebo. Previously weaned children were enrolled at 12-18 months and followed for 6 months with daily home visits for data collection and supplement administration. Anthropometric measures were done monthly.

Results

Five hundred fifty-five children were randomized: 277 to bLF and 278 to placebo; 65 dropped out; 147 894 doses were administered (92% compliance). Overall there were 91 446 child-days of observation and 1235 diarrhea episodes lasting 6219 days. The main pathogens isolated during diarrheal episodes were norovirus (35.0%), entero

SUBMITTER: Ochoa TJ 

PROVIDER: S-EPMC3547155 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature