P68/DdX5 supports β-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.

ABSTRACT: The DEAD box RNA helicase p68 (Ddx5) is an important androgen receptor (AR) transcriptional co-activator in prostate cancer (PCa) and is over-expressed in late stage disease. β-Catenin is a multifunctional protein with important structural and signalling functions which is up-regulated in PCa and similar to p68, interacts with the AR to co-activate expression of AR target genes. Importantly, p68 forms complexes with nuclear β-Catenin and promotes gene transcription in colon cancer indicating a functional interplay between these two proteins in cancer progression. In this study, we explore the relationship of p68 and β-Catenin in PCa to assess their potential co-operation in AR-dependent gene expression, which may be of importance in the development of castrate resistant prostate cancer (CR

SUBMITTER: Clark EL 

PROVIDER: S-EPMC3547877 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature