Evaluation of physical and functional protein-protein interaction prediction methods for detecting biological pathways.

ABSTRACT:

Background

Cellular activities are governed by the physical and the functional interactions among several proteins involved in various biological pathways. With the availability of sequenced genomes and high-throughput experimental data one can identify genome-wide protein-protein interactions using various computational techniques. Comparative assessments of these techniques in predicting protein interactions have been frequently reported in the literature but not their ability to elucidate a particular biological pathway.

Methods

Towards the goal of understanding the prediction capabilities of interactions among the specific biological pathway proteins, we report the analyses of 14 biological pathways of Escherichia coli catalogued in KEGG database using five protein-prote

SUBMITTER: Muley VY 

PROVIDER: S-EPMC3547882 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature