Role of GB virus C in HIV-1-infected and hepatitis C virus-infected hemophiliac children and adolescents.

ABSTRACT:

Background

GB Virus C (GBV-C) has been associated with a better prognosis of HIV-1 disease in adults. Little is known about prevalence and interaction between GBV-C, HIV-1, and/or hepatitis C virus (HCV) in hemophiliac children and adolescents.

Methods

A well-characterized cohort of HIV-1-infected and HIV-1-uninfected hemophiliac children and adolescents followed in the Hemophilia Growth and Development Study (HGDS) were evaluated using quantitative reverse transcription polymerase chain reaction to detect GBV-C RNA in samples from baseline and last follow-up visit.

Results

HIV-1-infected (n = 202) and HIV-1-uninfected (n = 119) patients had a low prevalence of GBV-C infection at baseline (0.9 and 0%), which increased at time of last follow-up visit to 25.2% and 26.3%

SUBMITTER: Tenckhoff S 

PROVIDER: S-EPMC3548052 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature