RNA-Seq and human complex diseases: recent accomplishments and future perspectives.

ABSTRACT: The availability of the human genome sequence has allowed identification of disease-causing mutations in many Mendelian disorders, and detection of significant associations of nucleotide polymorphisms to complex diseases and traits. Despite these progresses, finding the causative variations for most of the common diseases remains a complex task. Several studies have shown gene expression analyses provide a quite unbiased way to investigate complex traits and common disorders' pathogenesis. Therefore, whole-transcriptome analysis is increasingly acquiring a key role in the knowledge of mechanisms responsible for complex diseases. Hybridization- and tag-based technologies have elucidated the involvement of multiple genes and pathways in pathological conditions, providing insights into the ex

SUBMITTER: Costa V 

PROVIDER: S-EPMC3548270 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature