Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

ABSTRACT:

Background

Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents.

Objectives

We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother-child study.

Methods

Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires.

Results

Both acrylamide and glycidamide Hb adducts were associated with a statistically s

SUBMITTER: Pedersen M 

PROVIDER: S-EPMC3548277 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature