Animal use and lessons learned in the U.S. High Production Volume Chemicals Challenge Program.

ABSTRACT:

Background

Launched by the U.S. Environmental Protection Agency (EPA) in 1998, the High Production Volume (HPV) Challenge Program was developed to address the perceived gap in basic hazard information for the 2,800 chemicals produced or imported into the United States in quantities of ≥ 1 million pounds per year. Health and environmental effects data obtained from either existing information or through new vertebrate animal testing were voluntarily submitted by chemical companies (sponsors) to the U.S. EPA. Despite the potential for extensive animal testing, animal welfare guidelines were not provided until after the start of the program.

Objectives

We evaluated compliance with the animal welfare principles that arose from an agreement reached between the U.S. EPA and animal

SUBMITTER: Bishop PL 

PROVIDER: S-EPMC3548278 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature