Exposure of rats to environmental tobacco smoke during cerebellar development alters behavior and perturbs mitochondrial energetics.

ABSTRACT:

Background

Environmental tobacco smoke (ETS) exposure is linked to developmental deficits and disorders with known cerebellar involvement. However, direct biological effects and underlying neurochemical mechanisms remain unclear.

Objectives

We sought to identify and evaluate underlying neurochemical change in the rat cerebellum with ETS exposure during critical period development.

Methods

We exposed rats to daily ETS (300, 100, and 0 µg/m3 total suspended particulate) from postnatal day 8 (PD8) to PD23 and then assayed the response at the behavioral, neuroproteomic, and cellular levels.

Results

Postnatal ETS exposure induced heightened locomotor response in a novel environment on par initially with amphetamine stimulation. The cerebellar mitochondrial subproteo

SUBMITTER: Fuller BF 

PROVIDER: S-EPMC3548280 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature