Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models.

ABSTRACT:

Background

Acute coronary syndrome is a leading cause of death in developed countries. Follistatin-like 1 (FSTL1) is a myocyte-derived secreted protein that is upregulated in the heart in response to ischemic insult. Here, we investigated the therapeutic impact of FSTL1 on acute cardiac injury in small and large preclinical animal models of ischemia/reperfusion and dissected its molecular mechanism.

Methods and results

Administration of human FSTL1 protein significantly attenuated myocardial infarct size in a mouse or pig model of ischemia/reperfusion, which was associated with a reduction of apoptosis and inflammatory responses in the ischemic heart. Administration of FSTL1 enhanced the phosphorylation of AMP-activated protein kinase in the ischemia/reperfusion-injured hear

SUBMITTER: Ogura Y 

PROVIDER: S-EPMC3548325 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature