Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.

ABSTRACT:

Rationale

Atherosclerotic lesion formation is associated with the accumulation of oxidized lipids. Products of lipid oxidation, particularly aldehydes, stimulate cytokine production and enhance monocyte adhesion; however, their contribution to atherosclerotic lesion formation remains unclear.

Objective

To test the hypothesis that inhibition of aldehyde removal by aldose reductase (AR), which metabolizes both free and phospholipid aldehydes, exacerbates atherosclerotic lesion formation.

Methods and results

In atherosclerotic lesions of apolipoprotein (apo)E-null mice, AR protein was located in macrophage-rich regions and its abundance increased with lesion progression. Treatment of apoE-null mice with AR inhibitors sorbinil or tolrestat increased early lesion formation

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC3548455 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature