Early interventions to prevent psychosis: systematic review and meta-analysis.

ABSTRACT:

Objective

To determine whether any psychological, pharmacological, or nutritional interventions can prevent or delay transition to psychotic disorders for people at high risk.

Design

Systematic review and meta-analysis.

Data sources

Embase, Medline, PreMedline, PsycINFO, and CENTRAL were searched to November 2011 without restriction to publication status.

Review methods

Randomised trials comparing any psychological, pharmacological, nutritional, or combined intervention with usual services or another treatment. Studies of participants with a formal diagnosis of schizophrenia or bipolar disorder were excluded. Studies were assessed for bias, and relevant limitations were considered in summarising the results.

Results

11 trials including 1246 participants

SUBMITTER: Stafford MR 

PROVIDER: S-EPMC3548617 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature