Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.

ABSTRACT:

Background

Antisocial personality disorder (ASPD) is a psychiatric disorder characterized by a long-term pattern of manipulating, exploiting, or violating the rights of others.

Methods

Subjects ascertained for genetic studies of substance dependence (SD) and diagnosed with ASPD and comorbid SD were included in a two-stage genetic association study. In the discovery stage, 627 single nucleotide polymorphisms (SNPs) located in 179 candidate genes for addiction were analyzed in a case-control cohort and family-based cohort. The significant findings were replicated in an independent case-control cohort.

Results

One SNP, rs13134663, in the collagen XXV alpha 1 gene (COL25A1) was significantly associated with ASPD in both African Americans and European Americans (smallest p

SUBMITTER: Li D 

PROVIDER: S-EPMC3548659 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature