Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. A total of 603 patients were analyzed, representing the major etiologies of HCC (hepatitis B and C) collected from Western and Eastern countries. We observed three robust HCC subclasses (termed S1, S2, and S3), each correlated with clinical parameters su

SUBMITTER: Hoshida Y 

PROVIDER: S-EPMC3549578 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature