Infection with street strain rabies virus induces modulation of the microRNA profile of the mouse brain.

ABSTRACT:

Background

Rabies virus (RABV) causes a fatal infection of the central nervous systems (CNS) of warm-blooded animals. Once the clinical symptoms develop, rabies is almost invariably fatal. The mechanism of RABV pathogenesis remains poorly understood. Recent studies have shown that microRNA (miRNA) plays an important role in the pathogenesis of viral infections. Our recent findings have revealed that infection with laboratory-fixed rabies virus strain can induce modulation of the microRNA profile of mouse brains. However, no previous report has evaluated the miRNA expression profile of mouse brains infected with RABV street strain.

Results

The results of microarray analysis show that miRNA expression becomes modulated in the brains of mice infected with street RABV. Quantitat

SUBMITTER: Zhao P 

PROVIDER: S-EPMC3549733 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature