Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones.

ABSTRACT:

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Background

The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models wherein functional deficits of testosterone or FSH, produced after treatments with 20 mg/Kg/d of cyproterone acetate (CPA) per os, for a period of 15 days or 3 mg/Kg/d of fluphenazine decanoate (FD) subcutaneously, for a period of 60 days, respectively, affected the rate of sperm chromatin decondensation in vitro. These rat models have been used in the current study in order to delineate the putative roles of testosterone and FSH in the molecular mechanism underlying remodelling of sperm chromatin.

Results

We report that deficits of both t

SUBMITTER: Gill-Sharma MK 

PROVIDER: S-EPMC3549752 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature