Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua.

ABSTRACT:

Background

Toll-like receptors (Tlrs) are major molecular pattern recognition receptors of the innate immune system. Atlantic cod (Gadus morhua) is the first vertebrate known to have lost most of the mammalian Tlr orthologues, particularly all bacterial recognising and other cell surface Tlrs. On the other hand, its genome encodes a unique repertoire of teleost-specific Tlrs. The aim of this study was to investigate if these duplicate Tlrs have been retained through adaptive evolution to compensate for the lack of other cell surface Tlrs in the cod genome.

Results

In this study, one tlr21, 12 tlr22 and two tlr23 genes representing the teleost-specific Tlr family have been cloned and characterised in cod. Phylogenetic analysis grouped all tlr22 genes under a single clade, ind

SUBMITTER: Sundaram AY 

PROVIDER: S-EPMC3549756 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature