Sum of parts is greater than the whole: inference of common genetic history of populations.

ABSTRACT:

Background

Reconstructability of population history, from genetic information of extant individuals, is studied under a simulation setting. We do not address the issue of accuracy of the reconstruction algorithms: we assume the availability of the theoretical best algorithm. On the other hand, we focus on the fraction (1 - f) of the common genetic history that is irreconstructible or impenetrable. Thus the fraction, f, gives an upper bound on the extent of estimability. In other words, there exists no method that can reconstruct a fraction larger than f of the entire common genetic history. For the realization of such a study, we first define a natural measure of the amount of genetic history. Next, we use a population simulator (from literature) that has at least two features. Fir

SUBMITTER: Utro F 

PROVIDER: S-EPMC3549811 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature