FitSearch: a robust way to interpret a yeast fitness profile in terms of drug's mode-of-action.

ABSTRACT:

Background

Yeast deletion-mutant collections have been successfully used to infer the mode-of-action of drugs especially by profiling chemical-genetic and genetic-genetic interactions on a genome-wide scale. Although tens of thousands of those profiles are publicly available, a lack of an accurate method for mining such data has been a major bottleneck for more widespread use of these useful resources.

Results

For general usage of those public resources, we designed FitRankDB as a general repository of fitness profiles, and developed a new search algorithm, FitSearch, for identifying the profiles that have a high similarity score with statistical significance for a given fitness profile. We demonstrated that our new repository and algorithm are highly beneficial to researche

SUBMITTER: Lee M 

PROVIDER: S-EPMC3549813 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature