Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells.

ABSTRACT:

Background

Pancreatic cancer is one of the deadliest cancers with a 5-year survival rate of 6%. Therapeutic options are very limited and there is an unmet medical need for safe and efficacious treatments. Cancer cell metabolism and mitochondria provide unexplored targets for this disease. We recently identified a novel class of triphenylphosphonium salts, TP compounds, with broad- spectrum anticancer properties. We examined the ability of our prototypical compound TP421- chosen for its fluorescent properties - to inhibit the growth of pancreatic cancer cells and further investigated the molecular mechanisms by which it exerts its anticancer effects.

Methodology/principal findings

TP421 exhibited sub-micromolar IC(50) values in all the pancreatic cancer cell lines tested usin

SUBMITTER: Shabaik YH 

PROVIDER: S-EPMC3549929 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature