Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors.

ABSTRACT: Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely contribute to the highly dynamic processes at the implantation site. The present study was undertaken to further characterize the mechanisms involved in the regulation of endometrial stromal cell motility and to identify trophoblast-derived factors that modulate migration. Among local growth factors known to be present at the time of implantation, heparin-binding epidermal growth factor-like growth factor (HB-EGF) triggered chemotaxis (directed locomotion), whereas platelet-derived growth factor (PDGF)-BB elicited both chemotaxis and chemokinesis

SUBMITTER: Schwenke M 

PROVIDER: S-EPMC3549986 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature