Rotavirus infection: a perspective on epidemiology, genomic diversity and vaccine strategies.

ABSTRACT: For centuries, acute diarrhea has been a major cause of death in young children worldwide, and until 1973, before rotavirus was discovered; no infectious agents could be identified in about 80% of patients admitted to hospital with severe dehydrating diarrhea. Rotaviruses have now been shown to cause 40-50% of severe acute diarrhea in young children worldwide in both developing and developed countries. More than 600,000 young children die and approximately 2.4 million hospitalize annually from rotavirus disease, especially in South-East Asia and sub-Saharan Africa. Two safe and effective vaccines are now licensed in 100 countries but used in 17 countries. Rotarix (GSK) vaccine is derived from single attenuated human rotavirus G1P[8], representative of the most common serotype identified wo

SUBMITTER: Mukherjee A 

PROVIDER: S-EPMC3550723 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature