How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.

ABSTRACT:

Background and objective

The influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health, and lifespan. The objective of this paper is to investigate regularities of aging changes in different groups of individuals, including individuals with different genetic background, as well as their connections with health and lifespan.

Data and method

To reach this objective we used longitudinal data on four physiological variables, information about health and lifespan collected in the Framingham Heart Study (FHS), data on longevity alleles detected in earlier study, as well as methods of statistical modeling.

Results

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SUBMITTER: Yashin AI 

PROVIDER: S-EPMC3551204 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature