Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.

ABSTRACT:

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Infectious microorganisms often play a role in modulating the immune responses of their infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 transcription factor to regulate cell wall composition and the host-pathogen interface. In the absence of Rim101, C. neoformans exhibits an altered cell surface in response to host signals, generating an excessive and ineffective immune response that results in accelerated host death. This host immune response to the rim101Δ mutant strain is characterized by increased neutrophil influx into the infected lungs and an altered pattern of host cytokine expression compared to the response to wild-type cryptococcal infection. To identify genes associated with the observed phenotypes, we performed whole-ge

SUBMITTER: O'Meara TR 

PROVIDER: S-EPMC3551547 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature