CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival.

ABSTRACT:

Background

Our recent studies suggested that the chromodomain helicase DNA binding protein 1-like (CHD1L) gene plays an oncogenic role in human hepatocellular carcinoma. However, the status of CHD1L protein expression in ovarian cancer and its clinical/prognostic significance are obscure.

Methods

In this study, immunohistochemistry (IHC) for CHD1L was performed on a tissue microarray (TMA) containing 102 primary ovarian carcinomas and 44 metastatic lesions (omental metastasis). Receiver-operator curve (ROC) analysis was used to evaluate patients' survival status.

Results

There is an augmented tendency of CHD1L expression in ovarian carcinoma metastasis than in primary lesions (P<0.05). A significant association was found between positive expression of CHD1L and tumors

SUBMITTER: He WP 

PROVIDER: S-EPMC3551745 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature