A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria.

ABSTRACT:

Background

Inflammatory cytokinemia and systemic activation of the microvascular endothelium are central to the pathogenesis of Plasmodium falciparum malaria. Recently, 'parasite-derived' uric acid (UA) was shown to activate human immune cells in vitro, and plasma UA levels were associated with inflammatory cytokine levels and disease severity in Malian children with malaria. Since UA is associated with endothelial inflammation in non-malaria diseases, we hypothesized that elevated UA levels contribute to the endothelial pathology of P. falciparum malaria.

Methodology/principal findings

We measured levels of UA and soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-Selectin), thrombomodulin (sTM), tissue

SUBMITTER: Mita-Mendoza NK 

PROVIDER: S-EPMC3551755 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature