Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity.

ABSTRACT:

Background and aim

Assessment of serum concentration of lipopolysaccharide (LPS)-binding protein (LBP) has been suggested as a useful biomarker to indicate activation of innate immune responses to microbial products. We investigated LBP concentrations and associations with demographics, lifestyle factors, and common metabolic abnormalities in adults. We also examined if LBP concentrations were associated with common polymorphisms in genes coding for LBP (rs2232618), CD14 (rs2569190), and TLR4 (rs4986790), the molecules responsible for the innate immune response to LPS, or serum levels of soluble CD14 (sCD14) and proinflammatory cytokines.

Methods

Serum LBP was measured with a commercial immunoassay in a random sample of the adult population (n = 420, 45% males, age 18-92 yea

SUBMITTER: Gonzalez-Quintela A 

PROVIDER: S-EPMC3551812 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature