Ontology highlight
ABSTRACT:
SUBMITTER: Gut P
PROVIDER: S-EPMC3552031 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Nature chemical biology 20121202 2
Improving the control of energy homeostasis can lower cardiovascular risk in metabolically compromised individuals. To identify new regulators of whole-body energy control, we conducted a high-throughput screen in transgenic reporter zebrafish for small molecules that modulate the expression of the fasting-inducible gluconeogenic gene pck1. We show that this in vivo strategy identified several drugs that affect gluconeogenesis in humans as well as metabolically uncharacterized compounds. Most no ...[more]