Gastric antral injections of botulinum toxin delay gastric emptying but do not reduce body weight.

ABSTRACT:

Background & aims

Gastric injections of botulinum toxin A (BTA) have been reported to delay gastric emptying, increase satiation, and reduce body weight, but there are few data from randomized, placebo-controlled studies.

Methods

We enrolled 60 obese participants in a 24-week, double-blind, randomized, placebo-controlled, concealed allocation trial to compare the effects of gastric antral injections of BTA (100, 300, or 500 U) and saline placebo. The study was conducted at an outpatient clinical research unit. Participants were given one set of injections of BTA or placebo into the gastric antral muscularis propria by using endoscopic ultrasound guidance. Gastric emptying of solids was measured by scintigraphy; we also measured body weight, satiation (maximum tolerated volum

SUBMITTER: Topazian M 

PROVIDER: S-EPMC3552074 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature