Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner.

ABSTRACT:

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Noninvasive methods are needed to explore the heterogeneous tumor microenvironment and its modulation by therapy. Hybrid PET/MRI systems are being developed for small-animal and clinical use. The advantage of these integrated systems depends on their ability to provide MR images that are spatially coincident with simultaneously acquired PET images, allowing combined functional MRI and PET studies of intratissue heterogeneity. Although much effort has been devoted to developing this new technology, the issue of quantitative and spatial fidelity of PET images from hybrid PET/MRI systems to the tissues imaged has received little attention. Here, we evaluated the ability of a first-generation, small-animal MRI-compatible PET scanner to accurately depict heterogeneous pattern

SUBMITTER: Ng TS 

PROVIDER: S-EPMC3552656 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature