Identification of regulatory regions of bidirectional genes in cervical cancer.

ABSTRACT:

Background

Bidirectional promoters are shared promoter sequences between divergent gene pair (genes proximal to each other on opposite strands), and can regulate the genes in both directions. In the human genome, > 10% of protein-coding genes are arranged head-to-head on opposite strands, with transcription start sites that are separated by < 1,000 base pairs. Many transcription factor binding sites occur in the bidirectional promoters that influence the expression of 2 opposite genes. Recently, RNA polymerase II (RPol II) ChIP-seq data are used to identify the promoters of coding genes and non-coding RNAs. However, a bidirectional promoter with RPol II ChIP-Seq data has not been found.

Results

In some bidirectional promoter regions, the RPol II forms a bi-peak shape, which

SUBMITTER: Wang G 

PROVIDER: S-EPMC3552671 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature