Markers of hypercoagulability in CAD patients. Effects of single aspirin and clopidogrel treatment.

ABSTRACT:

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Background

Cardiovascular disease with disturbances in the haemostatic system, might lead to thrombotic complications with clinical manifestations like acute myocardial infarction (AMI) and stroke. Activation of the coagulation cascade with subsequent increased thrombin generation, characterizes a prothrombotic phenotype. In the present study we investigated whether prothrombotic markers were associated with risk factors and clinical subgroups in a cohort of patients with angiographically verified coronary artery disease (CAD). The patients were randomized to long-term treatment with the antiplatelet drugs aspirin or clopidogrel, and we further investigated the effect on hypercoagulability of such treatment for 1 year, of which limited data exists.

Methods

SUBMITTER: Bratseth V 

PROVIDER: S-EPMC3552672 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature