Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis.

ABSTRACT:

Background

Schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) are both complex diseases. Accumulated studies indicate that schizophrenia patients are prone to present the type 2 diabetes symptoms, but the potential mechanisms behind their association remain unknown. Here we explored the pathogenetic association between SCZ and T2D based on pathway analysis and protein-protein interaction.

Results

With sets of prioritized susceptibility genes for SCZ and T2D, we identified significant pathways (with adjusted p-value < 0.05) specific for SCZ or T2D and for both diseases based on pathway enrichment analysis. We also constructed a network to explore the crosstalk among those significant pathways. Our results revealed that some pathways are shared by both SCZ and T2D diseases

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3552677 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature