Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study.

ABSTRACT:

Background

High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined. We sought to identify members and functions of the intestinal microbial community associated with estrogen levels via enterohepatic recirculation.

Methods

Fifty-one epidemiologists at the National Institutes of Health, including 25 men, 7 postmenopausal women, and 19 premenopausal women, provided urine and aliquots of feces, using methods proven to yield accurate and reproducible results. Estradiol, estrone, 13 estrogen metabolites (EM), and their sum (total estrogens) were quantified in urine and feces by liquid chromatography/tandem mass

SUBMITTER: Flores R 

PROVIDER: S-EPMC3552825 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature