Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage.

ABSTRACT: Bacteriophage (phage), which are viruses that infect bacteria only, have shown promise as vehicles for targeted cancer gene therapy, albeit with poor efficiency. Recently, we generated an improved version of phage vectors by incorporating cis genetic elements of adeno-associated virus (AAV). This novel AAV/phage hybrid (AAVP) efficiently delivered systemically administered therapeutic genes to various tumor targets by displaying an integrin tumor-targeting ligand on the phage capsid. However, inherent limitations in bacteriophage mean that these AAVP vectors still need to be improved. One of the limitations of AAVP in mammalian cells may be its susceptibility to proteasomal degradation. The proteasome is upregulated in cancer and it is known that it constitutes a barrier to gene delivery b

SUBMITTER: Przystal JM 

PROVIDER: S-EPMC3553581 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature