Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum.

ABSTRACT: Large and functionally heterogeneous families of transcription factors have complex evolutionary histories. What shapes specificities toward effectors and DNA sites in paralogous regulators is a fundamental question in biology. Bacteria from the deep-branching lineage Thermotogae possess multiple paralogs of the repressor, open reading frame, kinase (ROK) family regulators that are characterized by carbohydrate-sensing domains shared with sugar kinases. We applied an integrated genomic approach to study functions and specificities of regulators from this family. A comparative analysis of 11 Thermotogae genomes revealed novel mechanisms of transcriptional regulation of the sugar utilization networks, DNA-binding motifs and specific functions. Reconstructed regulons for seven groups of ROK r

SUBMITTER: Kazanov MD 

PROVIDER: S-EPMC3553997 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature