Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study.

ABSTRACT:

Background

Childhood cancer survivors develop gastrointestinal cancer more frequently and at a younger age than the general population, but the risk factors have not been well-characterized.

Objective

To determine the risk and associated risk factors for gastrointestinal subsequent malignant neoplasms (SMNs) in childhood cancer survivors.

Design

Retrospective cohort study.

Setting

The Childhood Cancer Survivor Study, a multicenter study of childhood cancer survivors diagnosed between 1970 and 1986.

Patients

14 358 survivors of cancer diagnosed when they were younger than 21 years of age who survived for 5 or more years after the initial diagnosis.

Measurements

Standardized incidence ratios (SIRs) for gastrointestinal SMNs were calculated by using

SUBMITTER: Henderson TO 

PROVIDER: S-EPMC3554254 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature