Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort.

ABSTRACT:

Objective

To determine the extent of, and reasons for, ethnic differences in type 2 diabetes incidence in the U.K.

Research design and methods

Population-based triethnic cohort. Participants were without diabetes, aged 40-69 at baseline (1989-1991), and followed-up for 20 years. Baseline measurements included fasting and postglucose bloods, anthropometry, and lifestyle questionnaire. Incident diabetes was identified from medical records and participant recall. Ethnic differences in diabetes incidence were examined using competing risks regression.

Results

Incident diabetes was identified in 196 of 1,354 (14%) Europeans, 282 of 839 (34%) Indian Asians, and 100 of 335 (30%) African Caribbeans. All Indian Asians and African Caribbeans were first-generation migrants. Comp

SUBMITTER: Tillin T 

PROVIDER: S-EPMC3554271 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature