Nationwide registry-based analysis of cancer clustering detects strong familial occurrence of Kaposi sarcoma.

ABSTRACT: Many cancer predisposition syndromes are rare or have incomplete penetrance, and traditional epidemiological tools are not well suited for their detection. Here we have used an approach that employs the entire population based data in the Finnish Cancer Registry (FCR) for analyzing familial aggregation of all types of cancer, in order to find evidence for previously unrecognized cancer susceptibility conditions. We performed a systematic clustering of 878,593 patients in FCR based on family name at birth, municipality of birth, and tumor type, diagnosed between years 1952 and 2011. We also estimated the familial occurrence of the tumor types using cluster score that reflects the proportion of patients belonging to the most significant clusters compared to all patients in Finland. The clust

SUBMITTER: Kaasinen E 

PROVIDER: S-EPMC3554690 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature