Comparison of nevirapine plasma concentrations between lead-in and steady-state periods in Chinese HIV-infected patients.

ABSTRACT:

Objectives

To investigate the potential of nevirapine 200 mg once-daily regimen and evaluate the influence of patient characteristics on nevirapine concentrations.

Methods

This was a prospective, multicentre cohort study with 532 HIV-infected patients receiving nevirapine as a part of their initial antiretroviral therapy. Plasma samples were collected at trough or peak time at the end of week 2 (lead-in period) and week 4, 12, 24, 36, and 48 (steady-state period), and nevirapine concentrations were determined using a validated HPLC method. Potential influencing factors associated with nevirapine concentrations were evaluated using univariate and multivariate logistic regression.

Results

A total of 2348 nevirapine plasma concentrations were collected, including 1510 tr

SUBMITTER: Kou H 

PROVIDER: S-EPMC3554734 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature