Random parameter sampling of a generic three-tier MAPK cascade model reveals major factors affecting its versatile dynamics.

ABSTRACT: The mitogen-activated protein kinase (MAPK) pathway is considered to be a central block in many biological signaling networks. Despite the common core cascade structure, the activation of MAPK in different biological systems can exhibit different types of dynamic behaviors. Computer modeling may help to reveal the mechanisms underlying such variations. However, so far most computational models of the MAPK cascade have been system-specific, or to reflect a particular type among the wide spectrum of possible dynamics. To obtain a general and integrated view of the relationship between the dynamics of MAPK activation and the structures and parameters of the MAPK cascade, we constructed a generic model by comparing previous models covering different specific biological systems. We assumed that

SUBMITTER: Mai Z 

PROVIDER: S-EPMC3554771 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature