Combinatorial signaling through TLR-2 and CD86 augments activation and differentiation of resting B cells.

ABSTRACT: B cells are an integral component in mounting humoral immune responses and they are also crucial in programming T cell mediated immunity. Usually, B cell activation is initiated by recognition of antigen through B cell receptor (BCR), followed by its processing and presentation to T cells. But very little is known about BCR independent activation of B cells. Now, there is an increasing body of evidence indicating the combinatorial effect of innate and adaptive immune components in modulating the functions of B cells. In this study, we demonstrate the activation of resting B cells (RB) by simultaneous involvement of Toll like Receptor-2 (TLR-2) and costimulatory molecule, CD86. Interestingly, these B cells exhibited significant level of activation and proliferation. Furthermore, this proces

SUBMITTER: Jain S 

PROVIDER: S-EPMC3554778 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature